Bristol Myers Squibb's Iza-Bren cuts risk of progression or death by 59% in Phase 3 breast cancer trial

• Bristol Myers Squibb reported iza-bren outperformed chemotherapy in the Phase 3 PANKU-Breast01 breast cancer trial, reducing disease progression or death.
• The trial enrolled patients with advanced HR-positive, HER2-negative breast cancer whose disease had progressed despite prior chemotherapy.
• Safety was manageable, with no new safety signals identified; few patients discontinued treatment because of treatment-related adverse events.
• Results will be presented at ESMO 2026, running October 23-27 in Madrid, with simultaneous publication in The Lancet.

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