Natera partners with Angiex to use Signatera ctDNA test in AGX101 Phase I trial monitoring

• Natera entered a Signatera collaboration with Angiex to track treatment response in Angiex’s Phase I AGX101 solid-tumor trial.
• Agreement calls for longitudinal Signatera ctDNA testing during AGX101 dosing to assess molecular response alongside imaging.
• AGX101 targets TM4SF1 to deliver a cytotoxic payload to tumor cells, also tumor-associated endothelial cells, aiming to hit tumor vasculature.
• Data are intended to support development decisions for AGX101 by clarifying response when radiology results are uncertain.

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