Impact Therapeutics names IMP2794 KAT6A PROTAC degrader as preclinical candidate

• Impact Therapeutics nominated IMP2794 as a preclinical candidate, its first from a proprietary targeted protein degradation platform.
• Program targets KAT6A with a PROTAC degrader, showing more than 1,000-fold selectivity over KAT6B.
• Preclinical data showed in vitro tumor-cell cytotoxicity with minimal hematopoietic toxicity.
• In vivo studies showed antitumor activity in breast cancer CDX models, including both sensitive and insensitive settings.
• High oral bioavailability across multiple rodent and non-rodent species supported potential for strong human systemic exposure.

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