Circio teams with Avenue Biosciences in protein secretion research collaboration for gene therapy

• Circio entered a research collaboration with Avenue Biosciences to boost long-term production of secreted proteins in AAV gene therapy.
• The partners will combine Circio’s circVec circular RNA expression platform with Avenue’s machine learning-driven signal peptide engineering to improve secretion.
• Avenue will run initial high-throughput screening to select signal peptides; Circio will conduct follow-on in vitro and in vivo testing.
• The work targets higher protein output per dose, aiming to support broader applications in genetic and chronic diseases.

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