Karyopharm publishes corporate presentation highlighting selinexor Phase 3 trial readouts in 2026

• Karyopharm highlighted Phase 3 SENTRY topline data in JAK inhibitor-naïve myelofibrosis, showing selinexor with ruxolitinib met the co-primary endpoint on spleen volume reduction at week 24.
• SVR35 at week 24 was 49.8% for selinexor with ruxolitinib versus 28% for placebo with ruxolitinib, with an odds ratio of 2.58; p<0.0001.
• The symptom co-primary endpoint missed, with an adjusted mean difference of 0.97 in absolute total symptom score change at week 24; p=0.8246.
• Secondary analyses showed an overall survival signal with a hazard ratio of 0.43; nominal p=0.0222, with 11 deaths in the combination arm versus 12 in the control arm.
• Topline results were also flagged as expected mid-2026 from the Phase 3 XPORT-EC-042 trial of selinexor in TP53 wild-type endometrial cancer.

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