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    How Investors Are Reacting To ORIC Pharmaceuticals (ORIC) Big-Pharma Partnerships And Cancer Resistance Pipeline

    Simply Wall St·01/26/2026 01:16:53
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    • In recent weeks, Oric Pharmaceuticals has drawn increased attention as investors focused on its cancer resistance therapy pipeline, including Phase 1b candidates ORIC-114 and ORIC-944, and its collaborations with Pfizer, Bayer, and Johnson & Johnson.
    • An interesting development is how this combination of early-stage assets and partnerships with large pharmaceutical companies is reshaping perceptions of Oric’s potential role in oncology drug development.
    • Next, we’ll examine how this growing interest in Oric’s cancer resistance programs and big-pharma partnerships influences the company’s broader investment narrative.

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    What Is ORIC Pharmaceuticals' Investment Narrative?

    For ORIC Pharmaceuticals, the big-picture belief is that a focused bet on overcoming cancer resistance, backed by credible early data and blue-chip partners, can justify owning a pre-revenue, loss-making biotech. The recent attention around ORIC-114 and ORIC-944, alongside collaborations with Pfizer, Bayer, and Johnson & Johnson, reinforces the existing investment story rather than changing it outright, but it does sharpen the near-term catalysts. Phase 1b readouts and the potential move of ORIC-944 into Phase 3 in 2026 now look even more central to the thesis, with Janssen’s involvement around ORIC-114 underscoring clinical relevance. At the same time, the stock’s strong year-to-date move and the company’s ongoing cash burn, lack of revenue and shareholder dilution keep financing risk and execution risk firmly in focus.

    However, investors also need to weigh what happens if those trials do not progress as hoped. In light of our recent valuation report, it seems possible that ORIC Pharmaceuticals is trading beyond its estimated value.

    Exploring Other Perspectives

    ORIC 1-Year Stock Price Chart
    ORIC 1-Year Stock Price Chart
    Two fair value estimates from the Simply Wall St Community cluster between about US$18.58 and US$21 per share, underscoring how differently private investors can price ORIC’s early science. Set that against a business with no revenue, continuing losses of about US$135.27 million and heavy reliance on successful trial progression, and you can see why it pays to explore several viewpoints before forming a view on the stock’s longer term prospects.

    Explore 2 other fair value estimates on ORIC Pharmaceuticals - why the stock might be worth just $18.58!

    Build Your Own ORIC Pharmaceuticals Narrative

    Disagree with this assessment? Create your own narrative in under 3 minutes - extraordinary investment returns rarely come from following the herd.

    • A great starting point for your ORIC Pharmaceuticals research is our analysis highlighting 4 important warning signs that could impact your investment decision.
    • Our free ORIC Pharmaceuticals research report provides a comprehensive fundamental analysis summarized in a single visual - the Snowflake - making it easy to evaluate ORIC Pharmaceuticals' overall financial health at a glance.

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    This article by Simply Wall St is general in nature. We provide commentary based on historical data and analyst forecasts only using an unbiased methodology and our articles are not intended to be financial advice. It does not constitute a recommendation to buy or sell any stock, and does not take account of your objectives, or your financial situation. We aim to bring you long-term focused analysis driven by fundamental data. Note that our analysis may not factor in the latest price-sensitive company announcements or qualitative material. Simply Wall St has no position in any stocks mentioned.