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    Is Wells Fargo’s Anito-cel Endorsement Reframing the Investment Case for Arcellx (ACLX)?

    Simply Wall St·12/23/2025 05:12:44
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    • Earlier this year, Wells Fargo initiated coverage of Arcellx with an overweight rating, highlighting the company’s experimental CAR-T therapy anito-cel for multiple myeloma as a potential future pillar in blood cancer treatment.
    • The endorsement spotlights how Arcellx’s oncology immunotherapy platform is drawing increased attention as a possible contributor to next-generation multiple myeloma care options.
    • We’ll now examine how Wells Fargo’s focus on anito-cel as a potential multiple myeloma pillar reshapes Arcellx’s broader investment narrative.

    Find companies with promising cash flow potential yet trading below their fair value.

    What Is Arcellx's Investment Narrative?

    For Arcellx, the big-picture belief is that anito-cel can become a core treatment option in late-line multiple myeloma and eventually support a viable commercial franchise despite ongoing losses. The immediate catalysts still center on regulatory interactions and the path to a planned 2026 launch, supported by positive Phase 2 iMMagine-1 data, FDA RMAT and Fast Track designations, and the Kite partnership. Wells Fargo’s new overweight initiation does not change those scientific or regulatory milestones, but it does validate anito-cel’s perceived importance and may influence how investors weigh near-term setbacks or volatility after a 1-year share price decline. The key risks, though, remain executional: clinical, regulatory, manufacturing scale up with Kite, and the company’s ability to fund operations while staying unprofitable.

    However, investors should be aware of how long Arcellx might run losses before anito-cel scales. Despite retreating, Arcellx's shares might still be trading above their fair value and there could be some more downside. Discover how much.

    Exploring Other Perspectives

    ACLX 1-Year Stock Price Chart
    ACLX 1-Year Stock Price Chart
    Across four fair value estimates from the Simply Wall St Community, views stretch from about US$66 to a very large upper bound. Set against the current focus on anito-cel’s regulatory path and Arcellx’s ongoing losses, these differing opinions underline how widely expectations for future execution and commercialization can vary.

    Explore 4 other fair value estimates on Arcellx - why the stock might be worth over 8x more than the current price!

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    This article by Simply Wall St is general in nature. We provide commentary based on historical data and analyst forecasts only using an unbiased methodology and our articles are not intended to be financial advice. It does not constitute a recommendation to buy or sell any stock, and does not take account of your objectives, or your financial situation. We aim to bring you long-term focused analysis driven by fundamental data. Note that our analysis may not factor in the latest price-sensitive company announcements or qualitative material. Simply Wall St has no position in any stocks mentioned.