• EN

    • -+ 0.00%
    -+ 0.00%
    -+ 0.00%

    What Amgen (AMGN)'s Expanded UPLIZNA Approval in Generalized Myasthenia Gravis Means For Shareholders

    Simply Wall St·12/16/2025 05:12:53
    Listen to the news
    • Earlier this month, Amgen announced that the FDA approved UPLIZNA (inebilizumab-cdon) for adults with generalized myasthenia gravis who are anti-AChR and anti-MuSK antibody positive, adding a third U.S. indication to the therapy’s label.
    • The twice-yearly CD19-targeted B-cell therapy offers a differentiated option in a rare, autoimmune neuromuscular disease area where treatment choices have been relatively limited, reinforcing Amgen’s presence in specialized immunology.
    • We’ll now examine how this expanded UPLIZNA approval, with its low-frequency dosing and rare-disease focus, could reshape Amgen’s investment narrative.

    The end of cancer? These 29 emerging AI stocks are developing tech that will allow early identification of life changing diseases like cancer and Alzheimer's.

    Amgen Investment Narrative Recap

    To own Amgen, you have to believe its broad biologics portfolio, rare-disease focus and disciplined capital return can offset pricing pressure, biosimilar erosion and heavier R&D spending. The expanded UPLIZNA label reinforces the rare-disease and immunology story, but it does not materially change the near term focus on defending key franchises like Prolia and managing rising R&D and manufacturing investment, which remain the central risk to margins and cash generation right now.

    Among recent announcements, Amgen’s decision to lift its quarterly dividend to US$2.52 per share for Q1 2026 looks most relevant. It highlights management’s confidence in cash flow durability even as the company leans into higher late stage R&D and absorbs biosimilar pressure. For investors, that mix of income support and reinvestment sits alongside new approvals like UPLIZNA as part of the same catalyst: whether Amgen can keep funding growth while preserving financial flexibility.

    Yet while UPLIZNA broadens Amgen’s rare-disease reach, investors should still be aware of the mounting biosimilar and drug pricing threat that could...

    Read the full narrative on Amgen (it's free!)

    Amgen’s narrative projects $37.4 billion revenue and $8.2 billion earnings by 2028.

    Uncover how Amgen's forecasts yield a $322.88 fair value, in line with its current price.

    Exploring Other Perspectives

    AMGN 1-Year Stock Price Chart
    AMGN 1-Year Stock Price Chart

    The most optimistic analysts already expected Amgen’s revenue to reach about US$42.8 billion and earnings US$13.3 billion, and they see UPLIZNA-style launches as proof that volume driven growth and expanding margins could offset pricing and patent risks far more than consensus assumes.

    Explore 5 other fair value estimates on Amgen - why the stock might be worth as much as 69% more than the current price!

    Build Your Own Amgen Narrative

    Disagree with existing narratives? Create your own in under 3 minutes - extraordinary investment returns rarely come from following the herd.

    Searching For A Fresh Perspective?

    The market won't wait. These fast-moving stocks are hot now. Grab the list before they run:

    This article by Simply Wall St is general in nature. We provide commentary based on historical data and analyst forecasts only using an unbiased methodology and our articles are not intended to be financial advice. It does not constitute a recommendation to buy or sell any stock, and does not take account of your objectives, or your financial situation. We aim to bring you long-term focused analysis driven by fundamental data. Note that our analysis may not factor in the latest price-sensitive company announcements or qualitative material. Simply Wall St has no position in any stocks mentioned.