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    How Investors May Respond To Madrigal Pharmaceuticals (MDGL) Expanding Rezdiffra Access And Strengthening Finance Leadership

    Simply Wall St·12/14/2025 03:17:32
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    • Madrigal Pharmaceuticals recently appointed industry veteran Rita Thakkar as Senior Vice President and Chief Accounting Officer, while continuing to expand commercial access and international availability of its MASH therapy Rezdiffra, including a launch in Germany.
    • The combination of strengthened financial leadership and widening Rezdiffra uptake, supported by broad first-line payer coverage, highlights a focus on scaling disciplined, global growth in MASH treatment.
    • We’ll now examine how Rezdiffra’s broad first-line payer access and growing international footprint may influence Madrigal’s existing investment narrative.

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    Madrigal Pharmaceuticals Investment Narrative Recap

    To own Madrigal, you have to believe Rezdiffra can become a durable, globally adopted MASH therapy while the company manages single‑drug concentration risk and rising competition. The appointment of seasoned accounting leadership and broad first line payer access do not materially change the near term commercial execution catalyst or the key risk that any setback in Rezdiffra’s data or safety profile could hit revenues hard.

    Against this backdrop, H.C. Wainwright’s recent price target increase, citing strong Rezdiffra uptake and broad 2026 first line payer coverage, looks most relevant, because it directly ties current sentiment to how effectively Madrigal converts early access and international launches into sustained prescription growth during this critical commercialization phase.

    Yet investors should also be aware that, even with growing payer access, intensifying GLP 1 and MASH competition could still...

    Read the full narrative on Madrigal Pharmaceuticals (it's free!)

    Madrigal Pharmaceuticals' narrative projects $2.5 billion revenue and $822.9 million earnings by 2028.

    Uncover how Madrigal Pharmaceuticals' forecasts yield a $563.80 fair value, in line with its current price.

    Exploring Other Perspectives

    MDGL 1-Year Stock Price Chart
    MDGL 1-Year Stock Price Chart

    Six fair value estimates from the Simply Wall St Community span roughly US$460 to US$2,878, showing how far apart individual views on Madrigal’s potential can be. When you weigh those opinions against the reliance on a single lead asset and the importance of Rezdiffra’s ongoing clinical and commercial performance, it becomes even more important to compare several perspectives before deciding where you stand.

    Explore 6 other fair value estimates on Madrigal Pharmaceuticals - why the stock might be worth 20% less than the current price!

    Build Your Own Madrigal Pharmaceuticals Narrative

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    This article by Simply Wall St is general in nature. We provide commentary based on historical data and analyst forecasts only using an unbiased methodology and our articles are not intended to be financial advice. It does not constitute a recommendation to buy or sell any stock, and does not take account of your objectives, or your financial situation. We aim to bring you long-term focused analysis driven by fundamental data. Note that our analysis may not factor in the latest price-sensitive company announcements or qualitative material. Simply Wall St has no position in any stocks mentioned.