Wangshan Wangshui-B (02630) signed a licensing agreement with Xiansheng Pharmaceutical (02096) for new indications of VV116

Zhitong Finance App News, Wangshan Wangshui-B (02630) announced that the company and Xiansheng Pharmaceutical Group Co., Ltd. (02096) have signed a license agreement for the new indications of VV116. Under the agreement, the company will grant Xiansheng Pharmaceutical VV116 exclusive licensing rights for anti-respiratory syncytial virus (RSV) infection and anti-human metapulmonary virus (HMPV) infection indications in Greater China. Wangshan Wangshui and Xiansheng Pharmaceutical have joined forces to accelerate the clinical development and commercialization process of VV116 to benefit more patients by leveraging their respective R&D, production and commercialization advantages.

According to reports, VV116 is a novel oral nucleoside precursor. It received conditional marketing approval from the State Drug Administration in January 2023, and changed from conditional marketing approval to routine approval in January 2025 for the treatment of mild to moderate COVID-19 infections. Existing studies have shown that VV116 has broad-spectrum antiviral activity and shows a good inhibitory effect on various RNA viruses, including RSV.

In terms of anti-RSV, a phase II clinical trial of VV116 dry suspension for treating RSV infection in infants and young children has been completed, and based on the positive results of this clinical trial, it has been certified as a breakthrough treatment by the National Drug Administration (NMPA) Drug Evaluation Center (CDE). Preclinical studies have shown that VV116 shows significant antiviral effects in vitro and in animal models, and can improve pathological lung damage. Clinical pharmacokinetic studies have shown that VV116 has good oral absorption and linear pharmacokinetic properties, and infant formula has no significant effect on the bioavailability of its main metabolites. In clinical studies, the overall safety of VV116 was good, and no serious adverse events were found.