Moderna publishes presentation on phase I intismeran study in resected pancreatic cancer

• Moderna published phase I study results for adjuvant intismeran autogene with FOLFIRINOX in 20 patients with resected pancreatic ductal adenocarcinoma.
• Neoantigen-specific T-cell responses were detected in all 19 evaluable patients, including during concurrent chemotherapy.
• At median follow-up of approximately 17 months, 11 patients remained recurrence-free.
• One patient experienced grade 3 intismeran-related fatigue; no adverse events led to intismeran discontinuation.
• No deaths were reported; analyses were descriptive, with no formal hypothesis testing.

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