Regeneron Pharmaceuticals Announces Its Results From Phase 2 COURAGE Study Of Trevogrumab Shows 70% Prevention Of Muscle Loss Associated With Semaglutide Treatment; Lower Dose Of Trevogrumab Did Not Enhance Weight Loss Achieved With Semaglutide Alone

Regeneron Pharmaceuticals, Inc. (NASDAQ: REGN) today announced new results from the Phase 2 COURAGE trial evaluating trevogrumab (anti-GDF8/anti-myostatin) for its potential to prevent lean mass and muscle loss during GLP-1 receptor agonist-induced weight loss in people living with obesity. The results of the trial were presented during a Scientific Symposium at the European Association for the Study of Diabetes (EASD) Annual Meeting and is in press with The Lancet. Building on these positive findings, Regeneron is planning to initiate a Phase 2 trial evaluating trevogrumab in combination with GLP-1 receptor agonist-based therapies in older adults with obesity and decreased muscle mass and/or strength.