Arrowhead Pharmaceuticals Says Health Canada Authorizes REDEMPLO Interfering RNA Medicine To Lower Triglycerides in Adults with Familial Chylomicronemia Syndrome

Arrowhead Pharmaceuticals, Inc. (NASDAQ: ARWR) today announced that Health Canada has issued a Notice of Compliance (NOC) authorizing REDEMPLO™ (plozasiran), a small interfering RNA (siRNA) medicine, as an adjunct to diet to reduce triglycerides in adults with familial chylomicronemia syndrome (FCS) for whom standard triglyceride lowering therapies have been inadequate. FCS is a severe, rare disease characterized by triglyceride levels that can be 10 to 100 times higher than normal, leading to a substantially higher risk of developing acute, recurrent, and potentially fatal pancreatitis. FCS remains widely underdiagnosed and is estimated to affect between 1 and 13 people per million globally, though is approximately 100 times more common in parts of French Canada. REDEMPLO is the first and only Health Canada-approved siRNA medicine for people living with FCS that can be self-administered at home with a subcutaneous injection once every three months. Today's authorization follows the recent approval of REDEMPLO in the United States, as Arrowhead continues its efforts to increase global access to care for people living with FCS.