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IDEAYA Biosciences (IDYA): Valuation Check After Key Phase 2/3 Milestone for Darovasertib in Uveal Melanoma

Simply Wall St·12/25/2025 19:29:17
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IDEAYA Biosciences (IDYA) just hit a key milestone, completing enrollment in its Phase 2/3 OptimUM-02 trial for darovasertib in first line metastatic uveal melanoma, a step that may reshape expectations around future approvals.

See our latest analysis for IDEAYA Biosciences.

The milestone has arrived against a strong backdrop, with IDEAYA’s 90 day share price return of 38.89 percent and three year total shareholder return of 104.24 percent signaling momentum that investors increasingly see as justified by its advancing pipeline.

If this kind of late stage biotech progress has your attention, it could be a good moment to explore other specialised healthcare stocks that might be quietly setting up their next big catalyst.

With shares already up strongly and trading at roughly a 40 percent discount to consensus targets, investors now face a pivotal question: is IDEAYA still flying under the radar, or is the market already pricing in future growth?

Price-to-Sales of 14.6x: Is it justified?

On a price-to-sales basis, IDEAYA shares trade at a rich 14.6 times revenue, a level that suggests the market is already paying up for future success.

The price-to-sales multiple compares the company’s market value to its annual revenue, a common lens for unprofitable biotechs where earnings are not yet a meaningful guide.

For IDEAYA, a 14.6x price-to-sales ratio implies investors are assigning a substantial premium to its late stage pipeline and anticipated revenue growth, even though the company is currently loss making and not expected to turn profitable in the next three years.

That premium looks stretched in context, with IDEAYA trading above both the US Biotechs industry average of 12.4x and an estimated fair price-to-sales ratio of just 1.3x. These levels underline how far sentiment has run ahead of more conservative valuation anchors.

Explore the SWS fair ratio for IDEAYA Biosciences

Result: Price-to-Sales of 14.6x (OVERVALUED)

However, setbacks in pivotal trials or dilution from future fundraisings could quickly challenge the bullish case if clinical or partnership momentum stalls.

Find out about the key risks to this IDEAYA Biosciences narrative.

Build Your Own IDEAYA Biosciences Narrative

If you see the story differently or simply want to dig into the numbers yourself, you can build a tailored view in just a few minutes: Do it your way.

A great starting point for your IDEAYA Biosciences research is our analysis highlighting 1 key reward and 2 important warning signs that could impact your investment decision.

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This article by Simply Wall St is general in nature. We provide commentary based on historical data and analyst forecasts only using an unbiased methodology and our articles are not intended to be financial advice. It does not constitute a recommendation to buy or sell any stock, and does not take account of your objectives, or your financial situation. We aim to bring you long-term focused analysis driven by fundamental data. Note that our analysis may not factor in the latest price-sensitive company announcements or qualitative material. Simply Wall St has no position in any stocks mentioned.