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    Wave Life Sciences (WVE) Is Up 11.7% After Early WVE-007 Fat-Loss Data - What's Changed

    Simply Wall St·12/25/2025 02:45:39
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    • In December 2025, Wave Life Sciences reported interim Phase 1 INLIGHT data for its investigational siRNA therapy WVE-007, showing meaningful reductions in visceral and total body fat and increases in lean mass after a single 240 mg dose in metabolic disease patients.
    • Because WVE-007’s early results suggest simultaneous fat loss and lean mass preservation, it may address an important limitation of many existing obesity treatments.
    • Next, we’ll explore how this early WVE-007 efficacy and safety profile could influence Wave Life Sciences’ broader investment narrative.

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    Wave Life Sciences Investment Narrative Recap

    To own Wave Life Sciences, you basically have to believe its RNA platform can turn early clinical wins into approved products before the cash runs thin. The WVE-007 INLIGHT data strengthens the near term obesity catalyst, but also raises the stakes on execution and funding needs after the recent US$350.0 million equity raise, in a business that is still unprofitable and reliant on a few lead programs.

    The December 2025 follow on equity offering, totaling about US$350.0 million, is especially relevant here because it extends Wave’s runway just as WVE-007 moves from promising Phase 1 data toward larger, more expensive trials. That extra capital may help the company progress obesity and AATD programs toward their late 2025 and early 2026 readouts, while partially offsetting pressure from rising R&D spend and prior revenue declines.

    Yet, despite the encouraging WVE 007 data, investors should be aware of the risk that continued net losses and reliance on a few key trials could...

    Read the full narrative on Wave Life Sciences (it's free!)

    Wave Life Sciences' narrative projects $177.5 million revenue and $41.2 million earnings by 2028.

    Uncover how Wave Life Sciences' forecasts yield a $31.60 fair value, a 73% upside to its current price.

    Exploring Other Perspectives

    WVE 1-Year Stock Price Chart
    WVE 1-Year Stock Price Chart

    Three members of the Simply Wall St Community value Wave anywhere from US$31.6 to US$1,469.79, underscoring just how far opinions can stretch. You may want to weigh those views against the fact that the company remains unprofitable with widening losses and depends heavily on a small set of binary clinical catalysts.

    Explore 3 other fair value estimates on Wave Life Sciences - why the stock might be worth just $31.60!

    Build Your Own Wave Life Sciences Narrative

    Disagree with existing narratives? Create your own in under 3 minutes - extraordinary investment returns rarely come from following the herd.

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    This article by Simply Wall St is general in nature. We provide commentary based on historical data and analyst forecasts only using an unbiased methodology and our articles are not intended to be financial advice. It does not constitute a recommendation to buy or sell any stock, and does not take account of your objectives, or your financial situation. We aim to bring you long-term focused analysis driven by fundamental data. Note that our analysis may not factor in the latest price-sensitive company announcements or qualitative material. Simply Wall St has no position in any stocks mentioned.