CRISPR Therapeutics Issues Updates On Zugo-Cel, Investigational Allogeneic CAR T Targeting CD19, In Development For Autoimmune Disease And Hematologic Malignancies

-Four autoimmune patients treated to date demonstrate deep B-cell depletion sustained for at least 28 days; initial efficacy data suggest significant clinical improvement in patients dosed at the 100 million cell dose, with the first systemic lupus erythematosus (SLE) patient achieving Definitions of Remission in SLE (DORIS) remission through Month 6-

-An additional Phase 1 basket trial has been initiated for zugo-cel in refractory primary immune thrombocytopenic purpura (ITP) and warm autoimmune hemolytic anemia (wAIHA)-

-Single-agent activity with zugo-cel demonstrated an overall response rate (ORR) of 90% (9/10) and a complete response rate (CRR) of 70% (7/10) in patients dosed at the 600 million cell dose, with 67% (2/3) of patients in complete response (CR) after one year on study in relapsed or refractory (R/R) large B-cell lymphoma (LBCL)-

-Announces a collaboration and clinical supply agreement with Lilly to evaluate zugo-cel in combination with pirtobrutinib for aggressive B-cell lymphomas-

-Additional updates across autoimmune disease and hematological malignancies are expected in the second half of 2026-

ZUG, Switzerland and BOSTON, Dec. 22, 2025 (GLOBE NEWSWIRE) -- CRISPR Therapeutics (NASDAQ:CRSP), a biopharmaceutical company focused on creating transformative gene-based medicines for serious diseases, today provided updates on zugocaptagene geleucel (zugo-cel), formerly known as CTX112™, its investigational allogeneic CAR T targeting CD19, in development for autoimmune disease and hematologic malignancies.