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    Iovance Biotherapeutics (IOVA): Assessing Valuation After FDA Progress, Melanoma Data and Upgraded Analyst Targets

    Simply Wall St·12/20/2025 00:37:01
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    Iovance Biotherapeutics (IOVA) is back in the spotlight after fresh FDA related progress on its lifileucel cancer therapy and a Phase 2 melanoma update. These developments are reshaping how investors are sizing up the stock.

    See our latest analysis for Iovance Biotherapeutics.

    Those FDA tailwinds and trial updates have sparked a sharp turnaround in sentiment. The latest share price of $2.48 is supported by a 7 day share price return of 12.73 percent and a 90 day share price return of 20.98 percent, even though the 1 year total shareholder return of negative 66.40 percent and 5 year total shareholder return of negative 94.99 percent remind us the long term picture is still highly volatile and recovery focused rather than proven.

    If you are weighing Iovance against other oncology names, this could be a good moment to scan healthcare stocks and see what else matches your risk and growth appetite.

    With analyst targets clustered around 8 to 10 dollars while the stock trades below 3 dollars, is Iovance now a genuine bargain, or is the market already factoring in all that future growth?

    Most Popular Narrative: 69.9% Undervalued

    With Iovance Biotherapeutics closing at $2.48 versus a narrative fair value around $8.25, the most followed view implies substantial upside if its growth path lands.

    The analysts have a consensus price target of $9.1 for Iovance Biotherapeutics based on their expectations of its future earnings growth, profit margins and other risk factors. However, there is a degree of disagreement amongst analysts, with the most bullish reporting a price target of $20.0, and the most bearish reporting a price target of just $1.0.

    Read the complete narrative.

    Want to see how aggressive revenue ramps, thinner long term margins and a soaring future earnings multiple still add up to that fair value signpost? Dive in.

    Result: Fair Value of $8.25 (UNDERVALUED)

    Have a read of the narrative in full and understand what's behind the forecasts.

    However, setbacks in international approvals or weaker than expected Amtagvi demand could quickly erode those bullish assumptions and force investors to re-rate the stock.

    Find out about the key risks to this Iovance Biotherapeutics narrative.

    Build Your Own Iovance Biotherapeutics Narrative

    If you see the story playing out differently, or simply want to dig into the numbers yourself, you can build a custom view in just a few minutes: Do it your way.

    A great starting point for your Iovance Biotherapeutics research is our analysis highlighting 3 key rewards and 3 important warning signs that could impact your investment decision.

    Looking for more investment ideas?

    Ready for your next move beyond Iovance? Use the Simply Wall St Screener to pinpoint new, data backed opportunities before the crowd catches on.

    This article by Simply Wall St is general in nature. We provide commentary based on historical data and analyst forecasts only using an unbiased methodology and our articles are not intended to be financial advice. It does not constitute a recommendation to buy or sell any stock, and does not take account of your objectives, or your financial situation. We aim to bring you long-term focused analysis driven by fundamental data. Note that our analysis may not factor in the latest price-sensitive company announcements or qualitative material. Simply Wall St has no position in any stocks mentioned.