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Supernus Pharmaceuticals (SUPN): Assessing Valuation After Recent CNS Portfolio Progress and ONAPGO Approval

Simply Wall St·12/16/2025 12:14:12
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Supernus Pharmaceuticals (SUPN) has quietly rewarded patient investors, with the stock up around 30% this year and roughly 31% over the past year, outpacing many mid cap biotech peers.

See our latest analysis for Supernus Pharmaceuticals.

That climb has come as management pushed its central nervous system portfolio forward, with FDA approval for ONAPGO adding to optimism. The steady year to date share price return suggests momentum is still building from a longer track record of strong total shareholder returns.

If Supernus has you rethinking healthcare, it could be worth scanning other treatment makers too. You could start with healthcare stocks as a simple way to surface new ideas.

With shares still trading at a sizable discount to analyst targets despite robust revenue and earnings growth, the key question now is whether Supernus remains mispriced value or if the market is already factoring in its next leg of expansion.

Most Popular Narrative: 21.9% Undervalued

With Supernus closing at $47.28 against a narrative fair value of $60.50, the current gap hinges on how its growth runway is modeled.

Deep pipeline progress, along with advancements in late-stage candidates like SPN-820 (major depressive disorder) and SPN-443 (next-gen ADHD/CNS disorders), supports potential future earnings and revenue growth through innovative, differentiated therapies with potentially larger addressable markets.

Read the complete narrative.

If you are curious how this pipeline translates into that higher price tag, especially with margins and earnings heading in a surprising direction, you can review the narrative assumptions behind that valuation call.

Result: Fair Value of $60.50 (UNDERVALUED)

Have a read of the narrative in full and understand what's behind the forecasts.

However, persistent pricing pressure on core drugs and any clinical setbacks for SPN-820 or SPN-443 could quickly undermine the optimistic growth narrative.

Find out about the key risks to this Supernus Pharmaceuticals narrative.

Build Your Own Supernus Pharmaceuticals Narrative

If you see the story differently or want to dig into the numbers yourself, you can build a personalized view in just a few minutes with Do it your way.

A good starting point is our analysis highlighting 4 key rewards investors are optimistic about regarding Supernus Pharmaceuticals.

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This article by Simply Wall St is general in nature. We provide commentary based on historical data and analyst forecasts only using an unbiased methodology and our articles are not intended to be financial advice. It does not constitute a recommendation to buy or sell any stock, and does not take account of your objectives, or your financial situation. We aim to bring you long-term focused analysis driven by fundamental data. Note that our analysis may not factor in the latest price-sensitive company announcements or qualitative material. Simply Wall St has no position in any stocks mentioned.