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    Will Vykat XR Approval and Board Shift Reshape Soleno Therapeutics' (SLNO) Investment Narrative?

    Simply Wall St·12/14/2025 07:14:58
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    • Earlier this month, Soleno Therapeutics announced the passing of long-serving director and Audit Committee Chair William G. Harris, while indicating that existing Audit Committee member Andrew Sinclair, who qualifies as an “audit committee financial expert,” is expected to assume the chair role.
    • At the same time, the company has attracted uniformly positive analyst attention following FDA approval of Vykat XR, currently the only approved therapy for hyperphagia in Prader-Willi syndrome, signaling a shift into a new phase of its corporate story.
    • We will now examine how the Vykat XR approval, alongside Soleno’s evolving board leadership, shapes the company’s investment narrative going forward.

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    What Is Soleno Therapeutics' Investment Narrative?

    To own Soleno today, you essentially have to believe that Vykat XR can scale from a first-in-class approval into a durable, commercially meaningful PWS franchise, while the company manages the costs and execution risk that come with that transition. The recent passing of longtime audit chair William Harris is a loss of deep biopharma finance experience, but the expected promotion of Andrew Sinclair, alongside the recent addition of finance veteran Mark Hahn, suggests governance continuity rather than disruption. Given that, the near term catalysts still sit squarely around Vykat XR launch metrics, payer uptake and progress toward narrowing substantial operating losses, rather than board changes. Key risks remain the rich valuation, continued unprofitability and relatively new leadership team, which could amplify any commercial missteps.

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    Exploring Other Perspectives

    SLNO 1-Year Stock Price Chart
    SLNO 1-Year Stock Price Chart

    Four fair value estimates from the Simply Wall St Community span roughly US$43 to over US$430 per share, underscoring how differently individual investors see Soleno’s long term potential. Set against this wide dispersion, the company’s dependence on successful Vykat XR commercialization and a still unseasoned management team gives these contrasting views real weight, inviting you to examine several angles before forming a conclusion.

    Explore 4 other fair value estimates on Soleno Therapeutics - why the stock might be worth over 8x more than the current price!

    Build Your Own Soleno Therapeutics Narrative

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    This article by Simply Wall St is general in nature. We provide commentary based on historical data and analyst forecasts only using an unbiased methodology and our articles are not intended to be financial advice. It does not constitute a recommendation to buy or sell any stock, and does not take account of your objectives, or your financial situation. We aim to bring you long-term focused analysis driven by fundamental data. Note that our analysis may not factor in the latest price-sensitive company announcements or qualitative material. Simply Wall St has no position in any stocks mentioned.