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    KOMZIFTI Menin Inhibitor Data Might Change The Case For Investing In Kyowa Kirin (TSE:4151)

    Simply Wall St·12/10/2025 04:31:54
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    • Kura Oncology and Kyowa Kirin recently reported new Phase 1a/1b data showing that KOMZIFTI (ziftomenib), combined with venetoclax and azacitidine, produced encouraging antileukemic activity and a favorable safety profile in patients with acute myeloid leukemia harboring NPM1 mutations or KMT2A rearrangements, with results presented at the 67th ASH Annual Meeting.
    • An important insight is that these findings support ongoing registrational trials that aim to position KOMZIFTI as a core menin inhibitor option across both front-line and relapsed or refractory AML treatment regimens.
    • We’ll now examine how the encouraging safety and efficacy profile of KOMZIFTI in combination therapy could shape Kyowa Kirin’s investment narrative.

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    What Is Kyowa Kirin's Investment Narrative?

    For Kyowa Kirin, you really have to believe in its ability to convert a costly, slower‑growing specialty pharma base into higher quality growth driven by new therapies. The company is already guiding to steady FY2025 profits and modest dividend increases, but its premium valuation and pressure on margins keep execution firmly in focus. Against that backdrop, KOMZIFTI’s ASH data in combination therapy feels like a genuinely important short‑term catalyst: it reinforces the recent full FDA approval and strengthens the case that this menin inhibitor could become more deeply embedded in AML care if registrational trials succeed. At the same time, the update also underlines what can go wrong, from trial or regulatory setbacks to an already stretched earnings multiple that leaves less room for disappointment.

    But there is one risk around those trials that investors really should not overlook. Kyowa Kirin's share price has been on the slide but might be dropping deeper into value territory. Find out whether it's a bargain at this price.

    Exploring Other Perspectives

    TSE:4151 1-Year Stock Price Chart
    TSE:4151 1-Year Stock Price Chart

    The single Simply Wall St Community fair value estimate clusters at ¥2,585, highlighting how even private investors can settle on one tight view. Yet KOMZIFTI’s evolving clinical profile and Kyowa Kirin’s rich earnings multiple mean others may see far more upside or downside, so it is worth weighing several perspectives before deciding how this story fits into a portfolio.

    Explore another fair value estimate on Kyowa Kirin - why the stock might be worth as much as ¥2586!

    Build Your Own Kyowa Kirin Narrative

    Disagree with this assessment? Create your own narrative in under 3 minutes - extraordinary investment returns rarely come from following the herd.

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    This article by Simply Wall St is general in nature. We provide commentary based on historical data and analyst forecasts only using an unbiased methodology and our articles are not intended to be financial advice. It does not constitute a recommendation to buy or sell any stock, and does not take account of your objectives, or your financial situation. We aim to bring you long-term focused analysis driven by fundamental data. Note that our analysis may not factor in the latest price-sensitive company announcements or qualitative material. Simply Wall St has no position in any stocks mentioned.