MBX Biosciences Presents Preliminary Phase 1 Data for Obesity Candidate MBX 4291

• MBX Biosciences reported 7% mean weight loss at eight weeks in MBX 4291's first eight-person multiple-dose cohort, including two placebo recipients.
• The ongoing, blinded Phase 1 trial recorded no serious adverse events; one participant experienced mild diarrhea, with no nausea or vomiting.
• Twelve-week multiple-dose data for the obesity candidate are expected in the fourth quarter of 2026.
• Canvuparatide, an investigational once-weekly treatment for hypoparathyroidism, is in an ongoing Phase 3 trial targeting 160 patients.
• Cash of $481.6 million is expected to fund operations into 2029.

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