Johnson & Johnson's JNJ-6143 shows 75% tumor response rate in Phase 1 prostate cancer trial

• Johnson & Johnson reported Phase 1 results showing its investigational oral drug JNJ-6143 shrank tumors in heavily pretreated advanced prostate cancer patients.
• Most treatment-related side effects were mild to moderate, supporting selection of a 50-mg once-daily dose for Phase 2 development.
• Results were presented at the European Society for Medical Oncology Congress 2026.

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