Syneos Health-Tufts study finds clinical trial performance hinges on operating model design over sourcing choice

• Syneos Health-backed Tufts CSDD benchmarking study found no consistent clinical trial performance edge for in-house, full-service CRO, or FSP sourcing.
• Analysis covered 13 pharmaceutical sponsors, 81 development programs, 133 trials; operating model design emerged as the main driver of timelines, quality.
• Higher vendor counts correlated with longer protocol-to-database-lock timelines, more protocol amendments, more quality events, higher dropout risk in some settings.
• Results point to execution discipline, governance, partner coordination as the key levers, shifting focus from sourcing choice to operating model fit.

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