Just-Evotec Biologics starts Phase 1 trial of orthopoxvirus antibody cocktail JST-018 under US Department of War program

• Evotec unit Just – Evotec Biologics started a first-in-human Phase 1 trial of JST-018, an investigational monoclonal antibody cocktail targeting orthopoxviruses.
• Program was developed under the U.S. Department of War Accelerated Antibodies Program, positioning the asset as a prophylactic countermeasure for warfighters.
• Just – Evotec Biologics handled process development, regulatory submission, cGMP manufacturing at its J.POD Redmond site using continuous bioprocessing.
• Orthopoxvirus contract follows a 2022 plague antibodies award; the two contracts carry combined potential value of up to $123.9 million.

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