Ascletis initiates US Phase I trial of oral amylin agonist ASC36 in obesity

• Ascletis Pharma initiated a US Phase I trial of oral amylin receptor agonist ASC36 for obesity.
• No clinical results have been presented; the study will generate initial safety, dosing, drug-exposure, and early activity readouts.
• The trial enrolls 86 adults with obesity or overweight, testing single-ascending doses, then multiple-ascending doses.
• Preclinical studies showed meaningful weight loss, supporting the oral program’s differentiation versus injectable amylin competitors.
• Management framed ASC36 as a strategic validation of its oral peptide delivery platform, extending its metabolic disease pipeline.

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