Leads Biolabs advances Opamtistomig Phase II first-line ESCC trial into expansion stage

• Nanjing Leads Biolabs moved its Phase II study of Opamtistomig into an expansion stage for first-line esophageal squamous cell carcinoma.
• Safety run-in results have already been assessed, showing encouraging early activity with a favorable overall safety and tolerability profile.
• The expansion will run as a randomized head-to-head trial versus tislelizumab with chemotherapy, targeting a stronger first-line standard of care.
• Opamtistomig is being tested across 11 studies, supported by broad early signals without new technical data disclosed in this update.

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