GenFleet doses first patient in China Phase III trial of KRAS G12D inhibitor GFH375 for NSCLC

• GenFleet started a registrational Phase III China trial of oral KRAS G12D inhibitor GFH375 in previously treated KRAS G12D-mutant NSCLC.
• Trial tests GFH375 monotherapy versus docetaxel; more than 40 sites planned; first patient dosed at Nanjing Drum Tower Hospital.
• Program follows a separate registrational Phase III study in pancreatic cancer, positioning GFH375 among the most advanced candidates in KRAS G12D.
• Preliminary NSCLC monotherapy results were previously presented at ASCO and WCLC; updated late-line NSCLC data will be presented at WCLC.
• No targeted therapy is approved globally for KRAS G12D; GenFleet highlighted potential to shift second-line treatment options if Phase III succeeds.

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