Damora Therapeutics starts Phase 1/1b CLARITY-101 trial of DMR-001 in mutant CALR-driven ET, myelofibrosis

• Damora Therapeutics launched the Phase 1/1b CLARITY-101 trial of DMR-001 in mutant CALR-driven essential thrombocythemia, myelofibrosis.
• Initial trial results have not been presented; first data are expected from mid-2027.
• Study aims to assess safety, tolerability, early signs of benefit for a once-monthly subcutaneous antibody designed to block the disease driver.
• Development strategy targets patients who failed prior standard therapies, with a later expansion planned for earlier use, combination settings.

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