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Assessing ACADIA Pharmaceuticals (ACAD) Valuation After Its Strong 1-Year Share Price Rally

Simply Wall St·12/13/2025 18:17:25
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ACADIA Pharmaceuticals (ACAD) has been quietly rewarding patient investors, with the stock up roughly 57% over the past year and about 45% year to date. This performance reflects growing confidence in its CNS portfolio.

See our latest analysis for ACADIA Pharmaceuticals.

Zooming out, that strength is not a one week blip. The stock has logged a roughly mid teens 3 month share price return and a standout mid fifties 1 year total shareholder return, suggesting momentum is still building as investors reassess its growth runway and risk profile.

If ACADIA’s run has you thinking about what else could surprise to the upside in this space, now is a good time to explore healthcare stocks.

But after such a sharp rerating and only a modest discount to Wall Street’s target, is ACADIA still flying under the radar on valuation, or has the market already priced in its next leg of growth?

Most Popular Narrative Narrative: 7.4% Undervalued

With ACADIA Pharmaceuticals last closing at $27.15 against a most popular narrative fair value of $29.32, the story leans toward modest upside grounded in steady execution rather than hype.

ACADIA's pipeline momentum, with 9 disclosed programs and multiple late-stage clinical readouts expected by 2027, positions the company to significantly diversify its revenue streams, reducing risk from single-product dependence and providing potential for margin expansion as new products are launched.

Read the complete narrative.

Curious how a single set of growth, margin, and valuation assumptions turns today’s price into tomorrow’s potential upside, and what earnings path underpins that target? Dive in to see the numbers this narrative is built on.

Result: Fair Value of $29.32 (UNDERVALUED)

Have a read of the narrative in full and understand what's behind the forecasts.

However, tighter U.S. drug pricing and ACADIA's heavy reliance on NUPLAZID could pressure margins and quickly erode the expected upside in this narrative.

Find out about the key risks to this ACADIA Pharmaceuticals narrative.

Build Your Own ACADIA Pharmaceuticals Narrative

If this storyline does not quite match your view, or you prefer to dissect the numbers yourself, you can build a fresh take in just a few minutes, Do it your way.

A great starting point for your ACADIA Pharmaceuticals research is our analysis highlighting 4 key rewards and 2 important warning signs that could impact your investment decision.

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This article by Simply Wall St is general in nature. We provide commentary based on historical data and analyst forecasts only using an unbiased methodology and our articles are not intended to be financial advice. It does not constitute a recommendation to buy or sell any stock, and does not take account of your objectives, or your financial situation. We aim to bring you long-term focused analysis driven by fundamental data. Note that our analysis may not factor in the latest price-sensitive company announcements or qualitative material. Simply Wall St has no position in any stocks mentioned.